Applications of Sterilization by Ionizing Radiation

Pharmaceutical sterilization encompasses a wide range of products. This includes raw materials, active pharmaceutical ingredients (APIs), excipients, medications and other finished products, as well as packaging. Various products need sterilization to combat microbial contamination and ensure the safety of patients and healthcare professionals.

IONISOS offers two pharmaceutical sterilization solutions by irradiation: a reliable method that is quick to implement and adaptable to multiple uses.

Pharmaceutical Sterilization by Gamma Radiation

Gamma rays are currently the most widely used method for pharmaceutical sterilization. This method’s effectiveness lies in destroying the DNA of all microorganisms present on the product being treated. The principle is to expose the items to gamma rays emitted from cobalt-60.

Gamma irradiation of pharmaceutical products takes place in a secure chamber at room temperature. The exposure time is adjusted based on the desired dose and the density of the product being treated.

Advantages of gamma radiation for pharmaceutical sterilization:

• High penetration rate allowing the treatment of products already packaged in whole pallets;
• Ability to sterilize different products within the same order simultaneously by applying different doses;
• Applicable to all solid forms, packaging, and even liquids.

Pharmaceutical Sterilization by Beta Radiation

The other technique used to sterilize medical devices through ionization is beta ray treatment. This involves exposing the products to a bifacial electron beam. Within seconds, all microorganisms present are completely destroyed.

Beta sterilization of pharmaceutical products is conducted using a conveyor system at room temperature. This process leaves no residue and allows for the shipment of treated products after release by the authorized person.

Advantages of beta radiation for pharmaceutical sterilization:

• Cold and continuous treatment;
• Rapid sterilization speed;
• Ideal technique for treating items in their final packaging.

Advantages of Gamma and Beta Irradiation with IONISOS

IONISOS operates six treatment sites across France and Europe, each specializing in a specific technique. Each facility is equipped to handle large volumes and process them very quickly.

Here are the advantages of our company for medical and pharmaceutical device sterilization:

• Personalized service with a dedicated contact person;
• Expert advice on choosing the most suitable technique;
• ISO-certified treatment centers;
• Validation of the maximum dose according to the products being treated;
• Advanced quality control;
• True responsiveness in handling and shipping your packages and pallets.

Ensuring absolute sterility, services that meet your expectations, and effective and rapid treatment systems: these are the advantages of pharmaceutical sterilization through ionization.